If you had to live in a wine region or appellation, which one would it be, and why?
by “live in”, I mean Primary Residence; you would spend more time here than anywhere else.
For “wine region or appellation,” let’s keep it to some place that is widely-regarded as making fine wine. (sorry Minnesota, that means you’re Out!!)
Tuscany, the food and culture. Beautiful rolling hills and great wine.
If I can’t surf, I don’t want it, so;
Otago, NZ.
Bordeaux.
Hokkaido.
Cunning. 
That’s a very interesting question, Brian, and I look forward to reading what people’s ideas are!
I’ve seriously considered moving to the Bordeaux area, but in the end decided against it.
My wife is from Les Landes, the huge area south of Bordeaux, so she likes pine forests! We both love the Atlantic coast, with the unbroken sandy beaches and dunes, from Biarritz all the way up to Soulac at the tip of the Medoc and we did think about living in the Medoc itself. It’s quite easy to find a house at a reasonable price 15 minutes from the beach. But there are reasons why almost all Bordeaux CC owners choose not to live there: firstly and especially, the winter. It’s literally deserted. There are a few small towns but for any proper shopping and culture, it’s Bordeaux, at least an hour away (and often much more because of the traffic), which is the second reason.
Living in Bordeaux itself is fun - it’s a vibrant city all the year round - but the nearest beach is an hour away, or much more on Friday evenings and for the return trip on Sundays.
So we dropped the idea!
This could be a fun thread to follow.
Personally as I’m with young kids I have to take into account practical matters (unfortunately in this case) but luckily vines love beautiful places!
Not only because we have family there but Croatia would be high on the list, around Split or Zagreb. Great for many reasons and work really well with raising kids (education, sports, etc). perhaps somewhere in Istria could do like Pula.
Friuli and probably not too far from Udine - terrific wine country, one of the best places for practical everyday life in Italy.
For France/Germany, why not around Strasbourg or Freiburg - only visited briefly but very beautiful and seems nice for families as well. Wine country around Frankfurt (south or south west)?
In Spain, somewhere in the north like Galicia or Porto in Portugal?
Santa Barbara. Perfectly positioned for great wine country, great seafood and great Mexican food. I can’t live without chowing down a carne asada burrito at 2AM or a few birria and adobada tacos every Tuesday.
Reims. Accesible to Paris, good food, cute city and champagne 
Rias Baixas, nice weather, great seafood, chill town.
If New Zealand would take me…
I think there is a reasonable chance I will move to Alsace, somewhere in the Ribeauville area, when I retire in 15-20 years.
Hard to say. I would need to compare all the usual things one takes into account when choosing where to live: proximity to family and friends, cultural and social opportunities, weather, availability of quality medical care, economic considerations like cost of living and taxes, etc. Employment opportunities would be high on the list but I’m retired.
The wine produced wouldn’t figure into it at all since it’s possible to get anything from anywhere and my winery visiting days are over.
Santa Barbara, for all the reasons @KhaN said and more
I do like Santa Barbara and Tuscany. Sicily is lovely, if a bit out of the way. I’d also consider San Sebastián, if it’s close enough to Rioja to count. Gotta have the food and warm beach.
Basque country Spain or France.
Anderson Valley, having grown up there.
I like living in cities.
Bandol - at the sea … and quite close to Southern Rhone
Val d’Orcia in Tuscany. Perfectly placed between Montalcino and Montepulciano. Plus, if I get too old to drink wine, I can just spend my days enjoying the spectacular views!
New Zealand… probably Marlborough or Otago
Of the places I’ve been, it’s unquestionably Logroño/Rioja (and I live in Napa currently).
Easy access to Madrid/Bilbao/Saint-Sebastien/Pamplona and still big enough to live in itself.
Vinho Verde could also easily work given how close it is to Porto.
Which town? Cambados? A Guarda? Pontevedra?