I will second (third? fourth?) the recs for Coquine and Davenport. Both feature cooking that’s deceptively simple, but executed at a very high level. Service at both is great (for Portland) and both have fabulous wine lists.
Also, I’d echo Lee’s idea that you grab some pizza one of the nights you’re here. Lovely’s Fifty-Fifty is where I go with out-of-town friends because it’s a style that I haven’t really seen anywhere else. It’s very seasonal-veg focused (Sarah is the queen of the farmers market), with very creative topping combinations. I’m a pizza purist in many regards, but Lovely’s works. The ice cream is also fabulous. I also love Apizza Scholls (new haven style, I think [as a purist] the best pizza in the city) and Gracies, though I think they close in January.
All the Earl Ninsom restaurants are worth your time: Hat Yai’s southern-Thai fried chicken and roti makes for a fantastic casual lunch or dinner, Phuket Cafe for a hipper, more complete menu, and Eem’s Thai-meets-barbeque collab is one of those things that you wonder why it hadn’t happened before.
Both Shalom Y’all and Mediterranean Exploration Company (the original in the group) do fantastic modern-Middle-Eastern food. MEC is a bit more upscale and has a broader menu. I also like Tusk for a bit more veg-focused take on the genre.
OK Omens and Canard have two of my favorite wine lists–well selected, often with a couple years of age-- and the food at both is pretty good to quite good.
As far as wine shopping goes: E&R, Taborly Wines, and Vinopolis would be my picks. The first two have really great customer service, with really knowledgeable staff/ownership, and very well-thought-out selections. Vinopolis goes deeper, but service probably depends a bit more on who is there that day.
As for things to look for on the wine front: I secretly think PDX is one of the best markets in the country to buy wine. Lots of cool stuff comes in from Europe, and demand for allocations isn’t as fierce as many bigger cities, so interesting wines end up on store shelves (with the caveat that I don’t know what you love to drink). For local wines, I’d be on the hunt for some of the lower-tier Cameron wines (which don’t generally see distribution outside the PNW) and also some of their rarer wines (eg: Nebbiolo, Friulano). Also a few of the shops I mentioned get Thomas allocations, which is a nice way to try those wines without committing to a six-pack.
As for Portland wineries, Division is making very good stuff and has a tasting room, as is/does Teutonic and Portland Wine Company (Love and Squalor). Cutter Cascadia rents space from PWC and if Michael is around he’d be worth reaching out to for an appointment, his wines are really well done in styles/forms that aren’t as common for the area. I’m also Portland-based (though the winery is in Amity) so depending on schedules I’d be happy to host you at the house and go through some current releases. Obviously there are tons of wineries out in the valley, with many strong recs from the board. Not sure if you’ll have a car or not, but if you do it might be worth your time to sneak out and visit one or two. It’s definitely worth renting a car to get out and do a hike or two in the gorge (depending on weather) and/or on the coast.