For a week and a half, with Florence on your mind as a first choice, then definitely stick to Tuscany. Even a half day between starting to pack in one location, to finishing unpacking in another would make a dent in your limited holiday.
A car can be very useful in Tuscany, but for a first visit to Italy, make life simpler
Likewise I invariably recommend apartments for the extra space and convenience, but you are right to think that it becomes perhaps more of a chore or source of stress for a 1st holiday with no language.
However this doesn’t necessarily mean hotels, as say 4-5 days in Florence in a hotel, could be combined with the remainder in a convenient more rural location at an agriturismo. Italuans do these farmstays very well, indeed a number of wineries do this. The food is often excellent and either truly zero km, or at least pretty close to it - maybe a neighbour grows great fruit, so they have that to supplement the animals and veg they farm. Try www.agriturismo.it and look for somewhere strollable to a town or in a small town or large village. Buses are good in Tuscany and this can mean a bus service can connect you easily.
An easier option for something different to Florence would be Lucca or Montepulciano, both mostly pedestrianised, making them pretty good starting points, as fetting out in daylight to stroll around is one of the best ways to shake off jet lag, or similar draining journey. Although I suggested avoiding apartments, the Politian apartments in Montepulciano are excellent and the owner very helpful.
Another suggestion is Pisa. Many people dismiss Pisa as tourist tatty, overpriced and of no interest beyong the leaning tower in yhe field of miracles. They (imo) have got this almost 100% wrong. The area between either station and the field of miracles is absolutely as they suggest, and the field of miracles is certainly remarkable. What they criticise is not actually Pisa, byt the result of too many years of tourists seeing Pisa as a half day essential excursion on a whirlwind tour. They see the tat that tourism brings, and it is very much done to excess here. However if you stroll the 5 mins to the city itself, and it is bizarrely untainted by tourism. Restaurants offer very good food at very fair prices, the local churches are worth exploring, and the main shopping street is pretty decent. Pisa is also a decent international airport, very close to the city, meaning you start your holiday faster than if you have a long journey at the end of the flight.
Plenty more options, all within Tuscany, and a historic influx of Brits for holidays in ‘Chiantishire’ means English is understood pretty widely.
Finally, resist the temptation to base yourself in too many locations. 2 bases for 10 days should be more than enough, and helps maximise holiday time, and reduce wasted time packing and unpacking, checking in and out, waiting for buses, trains or other transport, and feeling slightly list and confused.
Have fun whatever you choose.